Programme
Tuesday, 13th December 2022
08:00Registration opens
08:50 - 09:00Welcome and opening by Prof. Jian Li (Monash University, Australia) and Prof. Falk Schreiber (University of Konstanz)
Session 1: Systems pharmacology in addressing challenges of antimicrobial resistance: From genomics to metabolomics
Discussion leader: Prof. Jian Li (Monash University, Australia)
09:00 - 09:25Prof. Ben Howden (University of Melbourne, Australia)
Genomics for understanding and tracking AMR
09:25 - 09:40Discussion
09:40 - 10:05A/Prof.Arun Konagurthu (Monash University, Australia)
Universal architectural concepts underlying protein folding patterns
10:05 - 10:20Discussion
10:20 - 10:50 Coffee break
Discussion leader: Prof. Falk Schreiber (University of Konstanz, Germany)
10:50 - 11:15A/Prof. Darren Creek (Monash University, Australia)
A systems pharmacology approach to reveal mechanisms of antimalarial drug action and resistance
11:15 - 11:30Discussion
11:30 - 11:55A/Prof. Berin Boughton (Murdoch University, Australia)
Imaging metabolic flux in vivo using mass spectrometry imaging
11:55 - 12:10Discussion
12:10 - 14:00 Lunch break (Information session by sponsors)
Session 2: Network modelling
Discussion leader: A/Prof. Tony Velkov (Monash University, Australia)
14:00 - 14:25Prof. Falk Schreiber (University of Konstanz, Germany)
Biological networks: computational methods from modelling standards to visual and immersive analytics
14:25 - 14:40Discussion
14:40 - 15:05Prof. Ming Chen (Zhejiang University, China)
Integrative Bioinformatics for Protein-Protein Interactions
15:05 - 15:20Discussion
15:20 - 15:50 Coffee break
Selected short talks from abstract submission
Discussion leader: Dr. Suzanne Parker (University of Queensland, Australia) and Dr. Khalid Iqbal (University of Hamburg, Germany)
15:50 - 16:05Jessica R. Tait (Monash University, Australia)
Describing the time-course of extracellular metabolites in a hollow-fibre infection model with transduction mathematical models
16:05 - 16:20Prof. Pablo Moscato (University of Newcastle, Australia)
Weighted l-pattern identification problem for explainable AI: its role in structure elicitation in toxicity studies
16:20 - 16:35Dr. Chris A. MacRaild (Monash University, Australia)
Integrating Protein Correlation Profiling with Cross-Linking Mass Spectrometry to build a comprehensive map of protein-protein interactions in the malaria parasite
Keynote presentation
Discussion leader: Prof. Jian Li (Monash University, Australia)
16:35 - 17:00Dr. Jiawei Wang (European Bioinformatics Institutes, UK)
Genome-scale phage protein annotation using deep learning
17:00 - 17:15Discussion
17:15 - 17:40Dr. Radu Botgros (European Medicines Agency, NL)
The role of PK/PD in the development and evaluation of new antibacterials-an EU perspective
17:40 - 17:50Discussion
18:00 - 18:45ECR session: Career development in the post-COVID era: Challenges and strategies
Discussion Leaders: Dr. Yan Zhu (Monash University, Australia), Ms. Sabrina Jaeger-Honz (University of Konstanz, Germany), Dr. Meiling Han (Monash University, Australia), Dr. Sue Chin Nang (Monash University, Australia)
Panel list: Nusaibah Abdul Rahim (University of Malaya, Malaysia), Jiawei Wang (European Bioinformatics Institutes, UK) , Yu-Wei Lin (Certara), A/Prof. Zongyuan Ge (Monash University, Australia), Shaz Sivanesan (SPP, Australia)
From 19:00 ECR dinner
Monash Conference Centre
Canapes and drinks
Wednesday, 14th December 2022
Session 3: PK/PD, machine learning, and molecular dynamics simulation in antimicrobial discovery
Discussion leader: Prof. Jason Roberts (University of Queensland, Australia)
09:00 - 09:25Prof. Brian Tsuji (University of Buffalo, USA)
New Strategies to Combat Gram-negative Resistance and Persistence
09:25 - 09:35Discussion
09:35 - 10:00Dr. Jon Stokes (McMaster University, Canada)
Machine learning for antibiotic discovery against Acinetobacter baumannii
10:00 - 10:10Discussion
10:10 - 10:40 Coffee break
Discussion leader: A/Prof. Zongyuan Ge (Monash University, Australia),
10:40 - 11:05Prof. Pablo Moscato (University of Newcastle, Australia)
Finding informative patterns in bioinformatics data: What have we learned from using (alpha,beta)-k-feature sets
11:05 - 11:15Discussion
11:15 - 11:40Prof. Alan Mark (University of Queensland, Australia)
Curved or linear? Mechanistic implications of the 3-dimensional structure of helical antimicrobial peptides
11:40 - 11:50Discussion
11:50 - 12:15A/Prof. Yuguang Mu (Nanyang Technological University, Singapore)
A machine-learning based score function to improve the protein-ligand interaction prediction
12:15 - 12:25Discussion
12:25 - 14:00 Lunch break (Information session by sponsors)
Session 4: Antimicrobial PK/PD/TD modelling
Selected short talks from abstract submission
Discussion leader: Dr. Nusaibah Abdul Rahim (University of Malaya, Malaysia) and Dr. Meiling Han (Monash University, Australia)
14:00 - 14:15 Siobhonne Breen (Monash University, Australia)
Mechanism-based modelling of the effect of inhaled aztreonam and tobramycin dosing regimens on hypermutable cystic fibrosis Pseudomonas aeruginosa isolates in a dynamic biofilm model
14:15 - 14:30 A/Prof. Xukai Jiang (Shandong University, China)
Crossing the barrier of lung surfactant: Rational design of novel lipopeptides against MDR Gram-negative bacteria
14:30 - 14:45 Dr. Yan Zhu (Monash University, Australia)
Quantification of non-culturable-but-viable Acinetobacter baumannii using a single-cell real-time imaging approach
14:45 - 15:00Dr. Xin Liu (University of Queensland, Australia)
Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation (ECMO)
Selected rapid fire presentations from abstract submission
Discussion Leader: Dr. Yu-Wei Lin (Certara) and Dr. Sue Chin Nang (Monash University, Australia)
15:05 - 15:10Dr. Yanqin Huang (University of Illinois at Chicago College of Pharmacy and Harvard Medical School, USA)
Plazomicin-Resistance in KPC-producing Klebsiella pneumoniae: A threat to a new therapeutic option?
15:10 - 15:15Dr. Xingchen Bian (Fudan University, China)
Modes of action of colistin and its combination with sulbactam against Acinetobacter baumannii using genome-scale metabolic model
15:15 - 15:20Dr. Zhi Ying Kho (Monash University, Australia)
spoT-mediated unique metabolic remodelling potentially underlies polymyxin tolerance in Acinetobacter baumannii
15:20 - 15:25Dr. Meiling Han (Monash University, Australia)
Arginine catabolism is vital to polymyxin-dependent resistant Acinetobacter baumannii
15:25 - 15:40 Coffee break
Discussion leader: A/Prof. Cornelia Landersdorfer (Monash University, Australia)
15:40 - 16:05A/Prof. Andrea Kwa (Duke-NUS Medical School and SingHealth-Duke-NUS Medicine ACP, Singapore)
Antibiotic combination therapy
16:05 - 16:15Discussion
16:15 - 16:40Prof. Lena Friberg (Uppsala University, Sweden)
Model-Informed Drug Development (MIDD) of antibiotics
16:40 - 16:50Discussion
16:50 - 17:15Dr Andreas Dräger (University of Tübingen, Germany)
Computationally Modeling the Human Microbiome of the Respiratory Tract
17:15 - 17:25Discussion
From 19:00 Conference dinner
Waterfront Southgate
Southgate Precinct, 20/3 Southgate Ave, Southbank
3 Course Set Menu
Thursday, 15th December 2022
Session 5: Antimicrobial PK/PD/TD modelling and emerging fields
Discussion leader: Dr. Zackery P. Bulman (University of Illinois at , USA)
09:15 - 09:40Dr. Zhixia (Grace) Y. Danielsen (FDA, USA)
Pharmacokinetic and Pharmacodynamic Considerations in the Development and Evaluation of Antibacterial Products
09:40 - 09:50Discussion
09:50 - 10:15Prof. Jason Roberts (University of Quensland, Australia)
Application of population PK into clinical care
10:15 - 10:25Discussion
10:25 - 10:50A/Prof. Gauri Rao (University of North Carolina at Chapel Hill, USA)
Moving from point-based analysis to systems-based modeling: Approaches to address antimicrobial resistance
10:50 - 11:00Discussion
11:00 - 11:15 Coffee break
Discussion Leader: Prof. Jian Li (Monash University, Australia)
11:15 - 11:40A/Prof. Vijaykrishna Dhanasekaran (University of Hong Kong, China)
Changing epidemiology of respiratory viruses during COVID-19
11:40 - 11:50Discussion
11:50 - 12:15A/Prof. Tony Velkov (Monash University, Australia)
Structure, function, and biosynthetic origin of octapeptin antibiotics active against extensively drug-resistant Gram-negative bacteria
12:15 - 12:25Discussion
12:25 - 14:00 Lunch break (Information session by sponsors)
Selected rapid fire presentations from abstract submission
Discussion Leader: A/Prof. Xukai Jiang (Shandong University) and Dr. Yan Zhu (Monash University, Australia)
14:05 - 14:10Dr. Mengyao Li (Shenzhen People's Hospital, China)
Cerebrospinal fluid proteome reveals novel insights into host-pathogen-antibiotic interactions in an Acinetobacter baumannii ventriculitis patient treated with intrathecal and intravenous polymyxin B
14:10 - 14:15Yi Li (Fudan University, China)
Causal Inference on Intestinal Microecology with Mendelian Randomization
14:15 - 14:20Dr. Jinxin Zhao (Monash University, Australia)
PhageGE: a webserver for integrated bacteriophage genomic analysis
14:20 - 14:25Dr. Yang Hu (Monash University, Australia)
Polymyxin B stalls crosstalk between host and the microbiome by reshaping the bacterial and host metabolome
Keynote presentation
Discussion leader: A/Prof. Gauri Rao (University of North Carolina at Chapel Hill, USA)
14:25 - 14:50A/Prof. Zongyuan Ge (Monash University, Australia)
Close the loop for Medical AI application
14:50 - 15:00Discussion
15:00 - 15:30 Coffee break
Funding opportunities and global initiative
International funding opportunities
Discussion leader: Prof. Jian Li (Monash University, Australia)
15:30 - 16:00Dr Zuoyu Xu (National Institute of Allergy and Infectious Diseases, USA)
Antibacterial Drug Discovery and Development Programs, Preclinical and Clinical Services at NIAID
16:00 - 16:10Discussion
16:10 - 16:40General meeting (e.g. global initiative)
16:40 - 17:00Awards
Prof. Jian Li (Monash University, Australia) and Prof. Falk Schreiber (University of Konstanz, Germany)
17:00 - 17:30Next conference and conclusion
Prof. Falk Schreiber (University of Konstanz, Germany)


ICAComP 2022 is organised by Monash University, Melbourne, Australia and University of Konstanz, Konstanz, Germany


Sponsor: Monash University

Sponsor: University of Konstanz

Contact

ICAComP 2022 local organiser (icacomp.adm
@gmail.com)
Monash University, Melbourne, Australia



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