Programme
Tuesday, 13th December 2022 |
08:00 | Registration opens |
08:50 - 09:00 | Welcome and opening by Prof. Jian Li (Monash University, Australia) and Prof. Falk Schreiber (University of Konstanz) |
Session 1: Systems pharmacology in addressing challenges of antimicrobial resistance: From genomics to metabolomics | |
Discussion leader: Prof. Jian Li (Monash University, Australia) | |
09:00 - 09:25 | Prof. Ben Howden (University of Melbourne, Australia) Genomics for understanding and tracking AMR |
09:25 - 09:40 | Discussion |
09:40 - 10:05 | A/Prof.Arun Konagurthu (Monash University, Australia) Universal architectural concepts underlying protein folding patterns |
10:05 - 10:20 | Discussion |
10:20 - 10:50 | Coffee break |
Discussion leader: Prof. Falk Schreiber (University of Konstanz, Germany) | |
10:50 - 11:15 | A/Prof. Darren Creek (Monash University, Australia) A systems pharmacology approach to reveal mechanisms of antimalarial drug action and resistance |
11:15 - 11:30 | Discussion |
11:30 - 11:55 | A/Prof. Berin Boughton (Murdoch University, Australia) Imaging metabolic flux in vivo using mass spectrometry imaging |
11:55 - 12:10 | Discussion |
12:10 - 14:00 | Lunch break (Information session by sponsors) |
Session 2: Network modelling | |
Discussion leader: A/Prof. Tony Velkov (Monash University, Australia) | |
14:00 - 14:25 | Prof. Falk Schreiber (University of Konstanz, Germany) Biological networks: computational methods from modelling standards to visual and immersive analytics |
14:25 - 14:40 | Discussion |
14:40 - 15:05 | Prof. Ming Chen (Zhejiang University, China) Integrative Bioinformatics for Protein-Protein Interactions |
15:05 - 15:20 | Discussion |
15:20 - 15:50 | Coffee break |
Selected short talks from abstract submission | |
Discussion leader: Dr. Suzanne Parker (University of Queensland, Australia) and Dr. Khalid Iqbal (University of Hamburg, Germany) | |
15:50 - 16:05 | Jessica R. Tait (Monash University, Australia) Describing the time-course of extracellular metabolites in a hollow-fibre infection model with transduction mathematical models |
16:05 - 16:20 | Prof. Pablo Moscato (University of Newcastle, Australia) Weighted l-pattern identification problem for explainable AI: its role in structure elicitation in toxicity studies |
16:20 - 16:35 | Dr. Chris A. MacRaild (Monash University, Australia) Integrating Protein Correlation Profiling with Cross-Linking Mass Spectrometry to build a comprehensive map of protein-protein interactions in the malaria parasite |
Keynote presentation | |
Discussion leader: Prof. Jian Li (Monash University, Australia) | |
16:35 - 17:00 | Dr. Jiawei Wang (European Bioinformatics Institutes, UK) Genome-scale phage protein annotation using deep learning |
17:00 - 17:15 | Discussion |
17:15 - 17:40 | Dr. Radu Botgros (European Medicines Agency, NL) The role of PK/PD in the development and evaluation of new antibacterials-an EU perspective |
17:40 - 17:50 | Discussion |
18:00 - 18:45 | ECR session: Career development in the post-COVID era: Challenges and strategies Discussion Leaders: Dr. Yan Zhu (Monash University, Australia), Ms. Sabrina Jaeger-Honz (University of Konstanz, Germany), Dr. Meiling Han (Monash University, Australia), Dr. Sue Chin Nang (Monash University, Australia) Panel list: Nusaibah Abdul Rahim (University of Malaya, Malaysia), Jiawei Wang (European Bioinformatics Institutes, UK) , Yu-Wei Lin (Certara), A/Prof. Zongyuan Ge (Monash University, Australia), Shaz Sivanesan (SPP, Australia) |
From 19:00 | ECR dinner Monash Conference Centre Canapes and drinks |
Wednesday, 14th December 2022 |
Session 3: PK/PD, machine learning, and molecular dynamics simulation in antimicrobial discovery | |
Discussion leader: Prof. Jason Roberts (University of Queensland, Australia) | |
09:00 - 09:25 | Prof. Brian Tsuji (University of Buffalo, USA) New Strategies to Combat Gram-negative Resistance and Persistence |
09:25 - 09:35 | Discussion |
09:35 - 10:00 | Dr. Jon Stokes (McMaster University, Canada) Machine learning for antibiotic discovery against Acinetobacter baumannii |
10:00 - 10:10 | Discussion |
10:10 - 10:40 | Coffee break |
Discussion leader: A/Prof. Zongyuan Ge (Monash University, Australia), | |
10:40 - 11:05 | Prof. Pablo Moscato (University of Newcastle, Australia) Finding informative patterns in bioinformatics data: What have we learned from using (alpha,beta)-k-feature sets |
11:05 - 11:15 | Discussion |
11:15 - 11:40 | Prof. Alan Mark (University of Queensland, Australia) Curved or linear? Mechanistic implications of the 3-dimensional structure of helical antimicrobial peptides |
11:40 - 11:50 | Discussion |
11:50 - 12:15 | A/Prof. Yuguang Mu (Nanyang Technological University, Singapore) A machine-learning based score function to improve the protein-ligand interaction prediction |
12:15 - 12:25 | Discussion |
12:25 - 14:00 | Lunch break (Information session by sponsors) |
Session 4: Antimicrobial PK/PD/TD modelling | |
Selected short talks from abstract submission | |
Discussion leader: Dr. Nusaibah Abdul Rahim (University of Malaya, Malaysia) and Dr. Meiling Han (Monash University, Australia) | |
14:00 - 14:15 | Siobhonne Breen (Monash University, Australia) Mechanism-based modelling of the effect of inhaled aztreonam and tobramycin dosing regimens on hypermutable cystic fibrosis Pseudomonas aeruginosa isolates in a dynamic biofilm model |
14:15 - 14:30 | A/Prof. Xukai Jiang (Shandong University, China) Crossing the barrier of lung surfactant: Rational design of novel lipopeptides against MDR Gram-negative bacteria |
14:30 - 14:45 | Dr. Yan Zhu (Monash University, Australia) Quantification of non-culturable-but-viable Acinetobacter baumannii using a single-cell real-time imaging approach |
14:45 - 15:00 | Dr. Xin Liu (University of Queensland, Australia) Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation (ECMO) |
Selected rapid fire presentations from abstract submission | |
Discussion Leader: Dr. Yu-Wei Lin (Certara) and Dr. Sue Chin Nang (Monash University, Australia) | |
15:05 - 15:10 | Dr. Yanqin Huang (University of Illinois at Chicago College of Pharmacy and Harvard Medical School, USA) Plazomicin-Resistance in KPC-producing Klebsiella pneumoniae: A threat to a new therapeutic option? |
15:10 - 15:15 | Dr. Xingchen Bian (Fudan University, China) Modes of action of colistin and its combination with sulbactam against Acinetobacter baumannii using genome-scale metabolic model |
15:15 - 15:20 | Dr. Zhi Ying Kho (Monash University, Australia) spoT-mediated unique metabolic remodelling potentially underlies polymyxin tolerance in Acinetobacter baumannii |
15:20 - 15:25 | Dr. Meiling Han (Monash University, Australia) Arginine catabolism is vital to polymyxin-dependent resistant Acinetobacter baumannii |
15:25 - 15:40 | Coffee break |
Discussion leader: A/Prof. Cornelia Landersdorfer (Monash University, Australia) | |
15:40 - 16:05 | A/Prof. Andrea Kwa (Duke-NUS Medical School and SingHealth-Duke-NUS Medicine ACP, Singapore) Antibiotic combination therapy |
16:05 - 16:15 | Discussion |
16:15 - 16:40 | Prof. Lena Friberg (Uppsala University, Sweden) Model-Informed Drug Development (MIDD) of antibiotics |
16:40 - 16:50 | Discussion |
16:50 - 17:15 | Dr Andreas Dräger (University of Tübingen, Germany) Computationally Modeling the Human Microbiome of the Respiratory Tract |
17:15 - 17:25 | Discussion |
From 19:00 | Conference dinner Waterfront Southgate Southgate Precinct, 20/3 Southgate Ave, Southbank 3 Course Set Menu |
Thursday, 15th December 2022 |
Session 5: Antimicrobial PK/PD/TD modelling and emerging fields | |
Discussion leader: Dr. Zackery P. Bulman (University of Illinois at , USA) | |
09:15 - 09:40 | Dr. Zhixia (Grace) Y. Danielsen (FDA, USA) Pharmacokinetic and Pharmacodynamic Considerations in the Development and Evaluation of Antibacterial Products |
09:40 - 09:50 | Discussion |
09:50 - 10:15 | Prof. Jason Roberts (University of Quensland, Australia) Application of population PK into clinical care |
10:15 - 10:25 | Discussion |
10:25 - 10:50 | A/Prof. Gauri Rao (University of North Carolina at Chapel Hill, USA) Moving from point-based analysis to systems-based modeling: Approaches to address antimicrobial resistance |
10:50 - 11:00 | Discussion |
11:00 - 11:15 | Coffee break |
Discussion Leader: Prof. Jian Li (Monash University, Australia) | |
11:15 - 11:40 | A/Prof. Vijaykrishna Dhanasekaran (University of Hong Kong, China) Changing epidemiology of respiratory viruses during COVID-19 |
11:40 - 11:50 | Discussion |
11:50 - 12:15 | A/Prof. Tony Velkov (Monash University, Australia) Structure, function, and biosynthetic origin of octapeptin antibiotics active against extensively drug-resistant Gram-negative bacteria |
12:15 - 12:25 | Discussion |
12:25 - 14:00 | Lunch break (Information session by sponsors) |
Selected rapid fire presentations from abstract submission | |
Discussion Leader: A/Prof. Xukai Jiang (Shandong University) and Dr. Yan Zhu (Monash University, Australia) | |
14:05 - 14:10 | Dr. Mengyao Li (Shenzhen People's Hospital, China) Cerebrospinal fluid proteome reveals novel insights into host-pathogen-antibiotic interactions in an Acinetobacter baumannii ventriculitis patient treated with intrathecal and intravenous polymyxin B |
14:10 - 14:15 | Yi Li (Fudan University, China) Causal Inference on Intestinal Microecology with Mendelian Randomization |
14:15 - 14:20 | Dr. Jinxin Zhao (Monash University, Australia) PhageGE: a webserver for integrated bacteriophage genomic analysis |
14:20 - 14:25 | Dr. Yang Hu (Monash University, Australia) Polymyxin B stalls crosstalk between host and the microbiome by reshaping the bacterial and host metabolome |
Keynote presentation | |
Discussion leader: A/Prof. Gauri Rao (University of North Carolina at Chapel Hill, USA) | |
14:25 - 14:50 | A/Prof. Zongyuan Ge (Monash University, Australia) Close the loop for Medical AI application |
14:50 - 15:00 | Discussion |
15:00 - 15:30 | Coffee break |
Funding opportunities and global initiative | |
International funding opportunities | |
Discussion leader: Prof. Jian Li (Monash University, Australia) | |
15:30 - 16:00 | Dr Zuoyu Xu (National Institute of Allergy and Infectious Diseases, USA) Antibacterial Drug Discovery and Development Programs, Preclinical and Clinical Services at NIAID |
16:00 - 16:10 | Discussion |
16:10 - 16:40 | General meeting (e.g. global initiative) |
16:40 - 17:00 | Awards Prof. Jian Li (Monash University, Australia) and Prof. Falk Schreiber (University of Konstanz, Germany) |
17:00 - 17:30 | Next conference and conclusion Prof. Falk Schreiber (University of Konstanz, Germany) |
ICAComP 2022 is organised by Monash University, Melbourne, Australia and University of Konstanz, Konstanz, Germany
![Sponsor: Monash University](International%20Conference%20on%20Antimicrobial%20Computational%20Pharmacology/Monash.png)
![Sponsor: University of Konstanz](International%20Conference%20on%20Antimicrobial%20Computational%20Pharmacology/Logo Uni KN_frei2.png)
Contact
ICAComP 2022 local organiser (icacomp.adm@gmail.com)
Monash University, Melbourne, Australia
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